Brian Cone Medical Group · Palos Verdes, California
Computational pathologist. Pathology AI & ML algorithm developer. Digital Pathology Tools & Systems Builder.
Board-certified in anatomic and clinical pathology, with hands-on experience spanning digital pathology, computer vision, clinical trials, laboratory operations, and translational research.
I design and write the full stack myself as a practicing pathologist—from whole-slide ingestion and native-resolution processing through model training, spatial analysis, heatmaps, quantification, and reporting. An RTX 5090 workstation with high-capacity system and GPU memory, fast NVMe storage, and ample compute runs deep pathology research and gigapixel slides at full scale.
I founded BCMG AI to develop and apply computer vision in pathology. My work spans whole-slide imaging, model and algorithm development, image analysis, companion diagnostics, multiplex workflows, and laboratory implementation. I also work directly with technical teams on validation, quality, and clinical operations.
Experience across AI research, companion diagnostics, pharmaceutical pathology, digital systems design, image analysis, clinical laboratory leadership, and regulatory readiness.
Deep pathology research, foundation model and encoder development, and next-generation image analysis.
AI and digital pathology tools, algorithm development, companion diagnostic autoscoring, and reporting.
Multiplex image analysis, IHC-to-mIF injection, and project salvage or recovery when an analysis needs a better path.
Whole-slide imaging, precision scanning, imaging systems integration, and image management system development.
Clinical and research lab digitization, AI implementation, and laboratory buildout with CAP/CLIA accreditation.
Clinical research organization services, pharma pathology reporting, and staining in CAP/CLIA-accredited laboratories.
Through BCMG, I own and operate a biorepository of more than 40,000 tissue blocks sourced through community practices in Southern California. Blocks representing human cancers and diseases across multiple organ systems are available for purchase for validation and biotechnology research. I also work with a network of pathology tissue and data purchasers and suppliers.
Consulting and employed roles across computational pathology, pharmaceutical development, clinical laboratories, and diagnostic practice.
Clinical trials and companion diagnostics; AI and digital pathology systems design; computational pathology research and development.
Image viewer and quality-control architecture.
Founding Medical Director, R&D (2023–2024); Director of Systems Integration (2022–2024); end-to-end virtual stains model development; CAP/CLIA and FDA regulatory affairs.
Clinical laboratory buildout for CAP and CLIA certification/registration and full laboratory director responsibilities.
Clinical-trial pharma pathology services plus image analysis and laboratory QA/QC direction.
Digital pathology services and Quantitative Continuous Scoring AI project development, including TROP2.
Clinical-trial and biotechnology/pathology research support.
Affiliated Pathologists Medical Group (APMG)
2020; 2022 · Laboratory Medical Director, Southern California Hospital at Culver CitySan Gabriel Valley Consulting Pathologist Medical Group
2022Cedars-Sinai Providence Tarzana Medical Center
2021–2022UCLA Medical Center
2020UCLA Medical Center · Chief Resident
2015–2019UCLA Medical Center
2014Kansas City University of Medicine
2015Arts & German Language and Literature · University of Missouri–Columbia
2008 · Honors research, Dr. Michael M. Roberts Embryonic Stem Cell Research GroupWhole-slide imaging and LIS software beta testing.
Interdepartmental pathology teaching for urology residents; medical student pathology labs in GI/GU, pulmonary/cardiac pathology, and hematopathology.
Pathology tutor.
Laboratory instructor, Introductory Biology for Science Majors.
Review of rapid diagnosis and subsequent final-diagnosis discrepancies.
A research record spanning computational pathology, virtual staining, thoracic and renal pathology, spatial analysis, and digital image analysis.
Do-it-yourself whole-slide imaging and experimental microscopy.
Co-investigator with Gregory Fishbein, MD · UCLA Translational Research Fund · 2019 USCAP platform presentation · manuscript PMID: 34330604.
Co-investigator with Anthony Sisk, DO · Kure-It Foundation Cancer Research Award · 2021 USCAP poster.
With Jing Yang, MD, and Huihui Ye, MD · 2020 USCAP poster.
In collaboration with Yair Rivenson, PhD, UCLA Electrical & Computer Engineering.
Principal investigator: Neda Moatamed, MD · 2018 CAP poster.
Collaboration with Dr. Wallace to establish the kit for computational pathology studies on USC Keck data, including work like the BRAF V600E and WDW pulmonary hypertension analyses.
A multi-encoder benchmark study.
Attention-based multiple-instance learning applied to phikon-v2 foundation-model whole-slide image features. Leave-one-out analysis of 18 patients and 128 slides achieved an AUROC of 0.975, 90% sensitivity, and 100% specificity.
Cone, B.; Ye, H.; et al. ELOC-mutated renal cell carcinoma is a rare indolent tumor with distinctive genomic characteristics. Modern Pathology. Accepted April 2025.
Cone, B.; Alexanian, S.; Rivenson, Y. Multi-modal spatial analysis of classic Hodgkin lymphoma microenvironment utilizing multiplex immunofluorescence and virtual staining. Society for Immunotherapy of Cancer, 2024. Poster.
Cone, B.; Kozikowski, R.; Alexanian, S.; Rivenson, Y. Virtual stain overlay for evaluating TME-specific PD-L1 expression in whole-slide images of lung cancer. Society for Immunotherapy of Cancer, 2023. Poster.
de Haan, K.; Kozikowski, R.; Alexanian, S.; Kobayashi, H.; Cone, B.; Rivenson, Y. Realtime, multiplexed rendering of lymphoma diagnostic panels from unstained tissue sections using virtual staining. American Society of Clinical Oncology, 2023. Abstract poster.
Fishbein, G.; Cone, B.; et al. Phosphorylated S6 ribosomal protein expression by immunohistochemistry correlates with de novo donor-specific HLA antibodies. Journal of Heart and Lung Transplantation, 2021.
Wadehra, M.; Cone, B.; et al. Aldehyde dehydrogenase isoforms and inflammatory cell populations are differentially expressed in term human placentas affected by intrauterine growth restriction. Placenta 81 (2019): 9–17.
Hanna, R.; Cone, B.; et al. Light & heavy chain deposition revealed by repeat renal biopsy after inconclusive initial biopsy. Nephrology @ Point of Care 5 (2019).
Cone, B.; Moatamed, N. Comparison of two clones of anti-PD-L1 antibodies on uterine cervical TMA by digital image analysis. College of American Pathologists National Meeting, 2018. Poster.
Cone, B.; Wallace, D. Sclerosing pneumocytoma: a case report. ASCP Lung Cancer Case of the Month; DxToolkit, June 2018.
Cone, B.; Wallace, D. Benign metastasizing leiomyoma: a case report. ASCP Lung Cancer Case of the Month; DxToolkit, May 2018.
Cone, B.; Koo, M.; Alexanian, S. Nasopharyngeal amelanotic melanoma with plasmacytoid features and CD138 expression. College of American Pathologists National Meeting, 2017. Poster.
Daria, G.; Cone, B.; Gregson, A.; Agopian, V. Gastrointestinal mucormycosis after orthotopic liver transplantation presenting as femoral nerve palsy. Transplantation Proceedings 49.7 (2017): 1608–1614.
Miller, K.; Cone, B.; White, R.; et al. Identification of a novel transcription factor impacting iron homeostasis. FASEB Journal 27.1 Supplement (2013): 769.5. Poster.
Brian Cone, Gregory Fishbein, Haodong Xu, et al. Springer Nature Switzerland AG, November 2022 eBook publication.
Board certification, active licensure, laboratory leadership, teaching, professional service, and continuing education.
Fellow & Alternate California Delegate
PresentMedical Director, AP/CP Laboratory
2023Education Committee · Website Committee
2022Program Evaluation Committee
2019